The Role of IGRAs in Assessing CMV-Specific Cell-Mediated Immunity.

This activity offers CE credit for:
1. Physicians (CME)
2. Nurses (CNE)

Credit Expiration Date: September 30, 2017


Hans H. Hirsch, MD, MSc
Professor, FMH Infectious Diseases,FMH Internal Medicine,FAMH Medical Microbiology Department of Biomedicine
University of Basel
Basel, Switzerland

Statement of Need

CMV is a serious threat to immunocompromised patients. Identifying more strategies for “harnessing the host immune response to CMV” would greatly reduce the negative impact that CMV has on immunocompromised individuals, particularly transplant patients.1

1. La Rosa, C, Diamond, DJ. The immune response to human CMV. Future Virol. 2012 Mar; 7(3):279-293.

Activity Goal

This program will inform health care providers about the importance of screening for CMV infection in transplant/ immunocompromised patients, and will look into IGRAs and their utility as an accurate predictor of CMV infection.

Learning Objectives

At the end of this CME activity, participants should be able to:


1. Review the challenges of managing cytomegalovirus (CMV) infection in haematopoietic cell transplant (HCT) patients
2. Discuss recent data on the potential clinical utility of IGRAs in assessing CMV-specific cell-mediated immunity in HCT patients
3. Be more aware of the clinical value that IGRAs may have on pre-emptive or prophylaxis strategies for CMV

Target Audience

The target audience of this program is physicians, surgeons, scientists, nurses, and pharmacists who are interested in the clinical and research aspects of haematopoietic cell transplantation (HCT).

Financial Support

This program is supported by an educational grant from Oxford Immunotec, Inc.

Credit Information

Accreditation Statement: This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of CME Outfitters, LLC and Jespersen & Associates, LLC. CME Outfitters, LLC is accredited by the ACCME to provide continuing medical education for physicians.

CME Outfitters, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CNE Credit (Nurses): Provider approved by the California Board of Registered Nursing, Provider Number CEP 15510, for 1.0 contact hours.

Post-tests, credit request forms, and activity evaluations must be completed online at (requires free account activation), and participants can print their certificate or statement of credit immediately (80% pass rate required). This website supports all browsers except Internet Explorer for Mac. For complete technical requirements and privacy policy, visit

Disclosure Declaration

It is the policy of CME Outfitters, LLC, to ensure independence, balance, objectivity, and scientific rigor and integrity in all of its CME/CE activities. Faculty must disclose to the participants any relationships with the commercial companies whose products or devices may be mentioned in faculty presentations, or with the commercial supporter of this CME/CE activity. CME Outfitters, LLC, has evaluated, identified, and attempted to resolve any potential conflicts of interest through a rigorous content validation procedure, use of evidence-based data/research, and a multidisciplinary peer review process. The following information is for participant information only. It is not assumed that these relationships will have a negative impact on the presentations.

Prof. Dr. med. Hans H. Hirsch, MD, MSc : no relationship to disclose

Jeffrey Helfand, DO (peer reviewer): no relationships to disclose

Caitlin Harrington (planning committee): no relationships to disclose

Unlabeled Use Disclosure

Faculty of this CME/CE activity may include discussions of products or devices that are not currently labeled for use by the FDA. Faculty members have been informed of their responsibility to disclose to the audience if they will be discussing off-label or investigational uses (any uses not approved by the FDA) of products or devices. CME Outfitters, LLC, the faculty, and Oxford Immunotec do not endorse the use of any product outside of the FDA-labeled indications. Medical professionals should not utilize the procedures, products, or diagnosis techniques discussed during this activity without evaluation of their patients for contraindications or dangers of use.

Questions about this activity? Call us at 877.CME.PROS (877.263.7767).